EFEK EKSTRAK ETHANOL DAUN KELOR (MORINGA OLEIFERA) TERHADAP PROTEKSI FUNGSI HATI DAN HISTOPATOLOGI TIKUS PUTIH (RATTUS NORVEGICUS) YANG DIINDUKSI KARBONTETRAKLORIDA (CCL4)
نویسندگان
چکیده
Abstrak
 Kerusakan hati menjadi salah satu penyakit dengan prevalensi yang tinggi khususnya di negara berkembang. Penelitian ini bertujuan untuk melihat adanya efek ekstrak ethanol daun kelor (Moringa oleifera) terhadap proteksi fungsi dan histopatologi tikus putih (Rattus norvegicus) diinduksi karbontetraklorida (ccl4). serta menentukan dosis efektif dari kombinasi tersebut. dilakukan secara eksperimental laboratorium menggunakan metode eksperimen desain post test only control group pada wistar. Tikus dibagi 5 kelompok, yaitu kelompok kontrol positif (ekstrak kurkuma), pembanding (NaCMC 1%) 3 pemberian variasi masing-masing 250 mg/kgBB, 500 mg/kgBB 750 mg/kgBB. Dilakukan pengamatan uji profil kimia darah meliputi SGOT SGPT dilanjutkan histopatologi. Hasil menunjukkan bahwa perbedaan perubahan hasil pengukuran (SGOT SGPT) antar selama 8 hari. perlakuan. Berdasarkan one way ANOVA terdapat tes bermakna (P<0,05). perbaikan struktur etanol kelor. Dapat disimpulkan memiliki kemampuan sebagai hepatoprotektor mg/kgBB.
 Abstract
 Liver damage is of the diseases with high prevalence especially in developing countries. This study aims to see effect extract Moringa oleifera leaves on liver function protection and histopathology white rat induced by carbontetrachloride (CCl4). determine effective dose combination. research was conducted experimentally using a laboratory experimental method design wistar rats. Rats were divided into groups, namely positive (curkuma extract), comparative groups giving extracts variations each mg / kgBB, kgBB kgBB. Observations made blood chemistry profile which included continued histopathological testing. The results showed that there differences changes measurements between for days. measurement profiles during treatment. Based significant (P <0.05). tests an improvement structure given leaves. It can be concluded has ability as hepatoprotector at
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ژورنال
عنوان ژورنال: Jurnal Ilmiah Ecosystem
سال: 2021
ISSN: ['2527-7286', '1411-3597']
DOI: https://doi.org/10.35965/eco.v21i1.702